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In volunteers with mild (ClCr = 50-eighty mL/min) and moderate (ClCr = 30-forty nine mL/min) renal impairment, the pharmacokinetics of a single oral dose of sildenafil (50 mg) were not altered. In volunteers with severe (ClCr ≤ 30 mL/min) renal impairment, sildenafil clearance was decreased, leading to increases in AUC (100%) and Cmax (88%) in comparison with age matched volunteers with no renal impairment.
Hepatic insufficiency.